1972•JNCI Journal of the National Cancer InstituteRequires access
Bone and Soft-Tissue Neoplasms in Cats Exposed to Radiostrontium
Jerrold Michael Ward, James F. Wright, Neal S. Nelson, Ezra Berman, C. G. Liddle, Alfred Hellman
Open publisher page 0 citations
Abstract
Four neoplasms of bone and soft tissues adjacent to bone developed in three cats from 274–609 days after initial oral administration of strontium-89. Neoplasms included a giant cell tumor, osteosarcoma, hemangiosarcoma, and fibrosarcoma. Cumulative dose to the skeleton of each cat varied from 1700–4850 rads. Feline leukemia virus was not detected in the neoplasms by a complement fixation test or ultrastructural examination. Comparative aspects of radionuclide carcinogenesis are discussed.