2012•Chemical CommunicationsRequires access

Simplifying native chemical ligation with an N-acylsulfonamide linker

Fabienne Burlina, Caroline Morris, Raymond Behrendt, Peter D. White, John Offer

Abstract

We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.

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Available abstract

Key concepts: Native chemical ligation, Ligation, Chemical ligation, Linker, Chemistry, Combinatorial chemistry, Chemical synthesis, Biochemistry