2006•Virology JournalOpen access

Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine

Stanley I. Martin, Robert John Wilkinson, Jay Alan Fishman

Abstract

The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 59 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Xenotransplantation, Virology, Biology, Recombinant DNA, Endogenous retrovirus, Retrovirus, Peripheral blood mononuclear cell, Recombinant virus