2010•AFRICAN JOURNAL OF BIOTECHNOLOGYOpen access

Anti-HIV-1 protease activities of crude extracts of some Garcinia species growing in Tanzania

J Magadula Joseph, Supinya Tewtrakul

Abstract

Eighteenth ethanol extracts from some Garcinia species in the Guttiferae (Clusiaceae) family collected in Tanzania were investigated for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC). Among the tested extracts, the fruit hulls of Garcinia semseii showed the most potent inhibitory activity against HIV-1 PR with an IC50 value of 5.7 µg/ml followed by the stem bark extracts of Garcinia edulis and Garcinia kingaensis with IC50 values of 9.2 and 15.2 µg/ml, respectively. Phytochemical screening of extracts indicated mostly the presence of phenolic and steroidal compounds. Key words: Garcinia species, clusiaceae, crude extracts, HIV-1 protease, inhibitory effect.

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Key concepts: Clusiaceae, Garcinia, Garcinia kola, Traditional medicine, Phytochemical, HIV-1 protease, Chemistry, Protease