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Epidermal Growth Factor Stimulates Growth Hormone Secretion from Superfused Rat Adenohypophyseal Fragments

Hitoshi Ikeda, Tomoaki Mitsuhashi, Ken Kubota, Nobuaki Kuzuya, Hidemasa Uchimura

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Abstract

Epidermal growth factor (EGF) stimulated GH secretion from superfused rat adenohypophyseal fragments in a dose-related manner (8-50 ng/ml). Secretion of PRL or TSH was not affected by EGF at concentrations up to 50 ng/ml. These results indicate that EGF may be a specific secretagogue for GH in rats.

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What this paper is about

Epidermal growth factor (EGF) stimulated GH secretion from superfused rat adenohypophyseal fragments in a dose-related manner (8-50 ng/ml). Secretion of PRL or TSH was not affected by EGF at concentrations up to 50 ng/ml. These results indicate that EGF may be a specific secretagogue for GH in rats.

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Available abstract

Epidermal growth factor (EGF) stimulated GH secretion from superfused rat adenohypophyseal fragments in a dose-related manner (8-50 ng/ml). Secretion of PRL or TSH was not affected by EGF at concentrations up to 50 ng/ml. These results indicate that EGF may be a specific secretagogue for GH in rats.

Key concepts: Endocrinology, Internal medicine, Secretagogue, Secretion, Epidermal growth factor, Biology, Prolactin, Chemistry

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Epidermal Growth Factor Stimulates Growth Hormone Secretion from Superfused Rat Adenohypophyseal Fragments — Research Paper | ScholarLens