1993•Biochemical PharmacologyRequires access

Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and squalene synthase

Louis Cohen, Arlène Van Vliet, Loes Roodenburg, Lucres M. C. Jansen, Marieke Griffigen

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Key concepts: Lovastatin, Pravastatin, Simvastatin, Reductase, Hydroxymethylglutaryl-CoA reductase, HMG-CoA reductase, Coenzyme A, Hep G2

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Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and squalene synthase — Research Paper | ScholarLens