2013•Bioorganic & Medicinal ChemistryOpen access

Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [131I] analogue as useful PET tracers for PI3-kinase

Duoli Sun, Basvoju A. Bhanu Prasad, Paul T. Schuber, Zhenghong Peng, David S. Maxwell, Diana V. Martin, Liwei Guo, Dongmei Han, Hiroaki Kurihara, David J. Yang, Juri G. Gelovani, Garth Powis, William G. Bornmann

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Key concepts: Wortmannin, Chemistry, Chemical synthesis, Covalent bond, Phosphoinositide 3-kinase, Kinase, Stereochemistry, Radiochemistry