2012•Bioorganic & Medicinal Chemistry LettersOpen access

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

Douglas J. Sheffler, Cody J. Wenthur, Joshua Andrew Bruner, Sheridan J. S. Carrington, Paige N. Vinson, Kiran K. Gogi, Anna L. Blobaum, Ryan D. Morrison, Mitchell Vamos, Nicholas D. P. Cosford, Shaun R. Stauffer, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley

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Key concepts: Chemistry, Metabotropic glutamate receptor, Metabotropic receptor, Glutamate receptor, Penetrant (biochemical), Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 3