Partial Hydatidiform Mole in a Medical Abortion with the Mifepristone/Misoprostol Combination

Gestational trophoblastic disease after an early elective medical abortion with the mifepristone/ misoprostol combination (MMC) is rare. We report a case of a young woman who was at 6–7 weeks of gestation who requested a medical abortion. The pretreatment ultrasonogram indicated a normal pregnancy. Passage of tissue ensued after the MMC, with good recovery. Postabortal ultrasonogram on day 14 showed the presence of intracavitary content. The patient declined our suggestion of serial ultrasonographic surveillance, and she was later lost to follow- up. Fifty days after the initial treatment, she again presented to our hospital with intermittent bleeding and an increase in the blood flow signal with a low resistance index in the uterus on color Doppler ultrasonography. After curettage, she was diagnosed as having a partial hydatidiform mole; she had complete regression of beta- human chorionic gonadotropin, monitored for 1 week after the evacuation. Obstetricians should be aware of the possibility of a partial hydatidiform mole after a medical abortion.