2007•The Journal of Cell BiologyOpen access

Building blood vessels—stem cell models in vascular biology

Lars Jakobsson, Johan Kreuger, Lena Claesson‐Welsh

Abstract

Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development.

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Key concepts: Vasculogenesis, Embryoid body, Biology, Embryonic stem cell, Angiogenesis, Cell biology, Stem cell, Embryogenesis