1977•Infection and ImmunityOpen access

Microtiter solid-phase radioimmunoassay for detection of Escherichia coli heat-labile enterotoxin

Harry B. Greenberg, David A. Sack, William J. Rodriguez, R. Bradley Sack, Richard G. Wyatt, Anthony R. Kalica, R L Horswood, R. M. Chanock, Albert Z. Kapikian

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Abstract

The development of a microtiter solid-phase radioimmunoassay for the detection of Vibrio cholerae enterotoxin and heat-labile Escherichia coli enterotoxin is described. The test is based on the immunological similarity between V. cholerae toxin and E. coli heat-labile toxin. The assay is easy to perform, quantitative, and at least as sensitive and specific as the Y-1 adrenal cell system.

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Key concepts: Enterotoxin, Vibrio cholerae, Escherichia coli, Radioimmunoassay, Microtiter plate, Biology, Toxin, Cholera toxin