2007•Antimicrobial Agents and ChemotherapyOpen access

Intrinsic Novobiocin Resistance in Staphylococcus saprophyticus

Anna Vickers, Ian Chopra, Alex J. O’Neill

Abstract

Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

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Key concepts: Novobiocin, Staphylococcus saprophyticus, Microbiology, Biology, Staphylococcus, Mutagenesis, Biochemistry, Chemistry