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2014•Journal of the American Academy of DermatologyOpen access

Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma

Tjinta Brinkhuizen, Marie G.H.C. Reinders, Michel van Geel, Annelot J.L. Hendriksen, Aimee D. C. Paulussen, Veronique J.L. Winnepenninckx, Kristien Keymeulen, Patricia M.M.B. Soetekouw, Maurice A. M. Van Steensel, Klara Mosterd

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Key concepts: Vismodegib, Smoothened, Medicine, Basal cell carcinoma, Hedgehog signaling pathway, Hedgehog, Patched, Internal medicine

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Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma — Research Paper | ScholarLens