2010•Toxicology and Industrial HealthRequires access

Caffeine as a photoprotective agent for diminishing phototoxicity

Yim Tong Szeto, Henry H. Y. Tong

Abstract

Skin whitening with Chinese herbal medicine has been used in ancient Asia. However, phototoxicity of the active ingredient limits the application. The modified comet assay was used in the current study to detect DNA crosslinking induced by phototoxicity. Result showed that caffeine at 5 µmol/L was able to reduce 5-methoxypsoralen-induced phototoxicity with ultraviolet C (UVC) exposure.

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Available abstract

Key concepts: Phototoxicity, Caffeine, Ultraviolet irradiation, Chemistry, Active ingredient, Pharmacology, Ingredient, Ultraviolet radiation