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The IgG Subclass Distribution in 659 Myeloma Sera

F Skvaril, A. Morell, S Barandun

Open publisher page 29 citations

Abstract

Abstract. The IgG subclass of 659 IgG myeloma proteins was determined with subclass‐specific antisera in agar precipitation technique. The following distribution was found: IgG1, 80%; IgG2, 10%; IgG3, 6.4%; IgG4, 3.6%. In addition, the light chain distribution among myeloma proteins of the subclasses was studied. The K/L ratio of the IgG1 proteins was 1.7; IgG2, 2.05; IgG3, 2.2; and IgG4, 3.0. These ratios did not differ significantly. In 9 sera with IgG double M‐components, the combination IgG1‐IgG4 was found to be predominant.

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What this paper is about

Abstract. The IgG subclass of 659 IgG myeloma proteins was determined with subclass‐specific antisera in agar precipitation technique. The following distribution was found: IgG1, 80%; IgG2, 10%; IgG3, 6.4%; IgG4, 3.6%. In addition, the light chain distribution among myeloma proteins of the subclasses was studied. The K/L ratio of the IgG1 proteins was 1.7; IgG2, 2.05; IgG3, 2.2; and IgG4, 3.0. These ratios did not differ significantly. In 9 sera with IgG double M‐components, the combination IgG1‐IgG4 was found to be predominant.

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Available abstract

Abstract. The IgG subclass of 659 IgG myeloma proteins was determined with subclass‐specific antisera in agar precipitation technique. The following distribution was found: IgG1, 80%; IgG2, 10%; IgG3, 6.4%; IgG4, 3.6%. In addition, the light chain distribution among myeloma proteins of the subclasses was studied. The K/L ratio of the IgG1 proteins was 1.7; IgG2, 2.05; IgG3, 2.2; and IgG4, 3.0. These ratios did not differ significantly. In 9 sera with IgG double M‐components, the combination IgG1‐IgG4 was found to be predominant.

Key concepts: Subclass, Multiple myeloma, Myeloma protein, Distribution (mathematics), Antiserum, Antibody, Immunoglobulin light chain, Immunoglobulin G

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