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2014•Organic Chemistry InternationalOpen access

Synthesis of Novel Symmetrical and Unsymmetrical o-Phthalic Acid Diamides

Padam Praveen Kumar, Yervala Dathu Reddy, Chittireddy Venkata Ramana Reddy, Bhoomireddy Rama Devi, Pramod Kumar Dubey

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Abstract

Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONR1R1] , unsymmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONR1R2] , and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONHAr] , respectively.

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Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONR1R1] , unsymmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONR1R2] , and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONHAr] , respectively.

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Available abstract

Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONR1R1] , unsymmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONR1R2] , and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides [o-R1R1NCOC6H4CONHAr] , respectively.

Key concepts: Chemistry, Algorithm, Computer science

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