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1994•Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyRequires access

Pneumocystis carinii Pneumonia Prophylaxis During Pregnancy

Rita T. Connelly, David L. Lourwood

Open publisher page 7 citations

Abstract

The frequency of human immunodeficiency virus (HIV) infection among pregnant women is increasing. Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in HIV-infected patients, and prophylaxis is an important part of decreasing morbidity. Trimethoprim-sulfamethoxazole (TMP-SMX), pentamidine, and dapsone, alone or in combination with pyrimethamine, are the most commonly used drugs for PCP prophylaxis in the nonpregnant HIV-infected population. Trimethoprim-sulfamethoxazole, however, has the potential for adverse effects in the fetus. Limited data are available for the other agents administered as prophylaxis of PCP.

About this research paper

What this paper is about

The frequency of human immunodeficiency virus (HIV) infection among pregnant women is increasing. Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in HIV-infected patients, and prophylaxis is an important part of decreasing morbidity. Trimethoprim-sulfamethoxazole (TMP-SMX), pentamidine, and dapsone, alone or in combination with pyrimethamine, are the most commonly used drugs for PCP prophylaxis in the nonpregnant HIV-infected population. Trimethoprim-sulfamethoxazole, however, has the potential for adverse effects in the fetus. Limited data are available for the other agents administered as prophylaxis of PCP.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The frequency of human immunodeficiency virus (HIV) infection among pregnant women is increasing. Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in HIV-infected patients, and prophylaxis is an important part of decreasing morbidity. Trimethoprim-sulfamethoxazole (TMP-SMX), pentamidine, and dapsone, alone or in combination with pyrimethamine, are the most commonly used drugs for PCP prophylaxis in the nonpregnant HIV-infected population. Trimethoprim-sulfamethoxazole, however, has the potential for adverse effects in the fetus. Limited data are available for the other agents administered as prophylaxis of PCP.

Key concepts: Pneumocystis carinii, Pentamidine, Trimethoprim, Dapsone, Medicine, Sulfamethoxazole, Pneumonia, Pyrimethamine

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