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Natural killer cell function in atopic dermatitis

Finn Schultz Larsen, Annelise Sparre Jørgensen, Niels Grunnet

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Abstract

The natural killer (NK) cell function was examined in the peripheral blood mononuclear cells of 14 patients with moderate or severe atopic dermatitis. There were significantly impaired NK cell responses in the atopic patients as compared to the control group. This impairment showed a negative correlation with log IgE concentration in the scrum. These findings prompt consideration of a relationship between decreased NK cell activity and the familiar enhanced susceptibility to viral infections in patients with atopic dermatitis.

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What this paper is about

The natural killer (NK) cell function was examined in the peripheral blood mononuclear cells of 14 patients with moderate or severe atopic dermatitis. There were significantly impaired NK cell responses in the atopic patients as compared to the control group. This impairment showed a negative correlation with log IgE concentration in the scrum. These findings prompt consideration of a relationship between decreased NK cell activity and the familiar enhanced susceptibility to viral infections in patients with atopic dermatitis.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The natural killer (NK) cell function was examined in the peripheral blood mononuclear cells of 14 patients with moderate or severe atopic dermatitis. There were significantly impaired NK cell responses in the atopic patients as compared to the control group. This impairment showed a negative correlation with log IgE concentration in the scrum. These findings prompt consideration of a relationship between decreased NK cell activity and the familiar enhanced susceptibility to viral infections in patients with atopic dermatitis.

Key concepts: Atopic dermatitis, Peripheral blood mononuclear cell, Immunology, Medicine, Natural killer cell, Immunoglobulin E, Cell, Allergy

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