1969•Journal of Pharmacy and PharmacologyRequires access

A quantitative chromatographic method for the determination of purity of oxytetracycline

F. James Bailey

Abstract

Abstract A chromatographic method for the determination of oxytetracycline is described, employing a hexane-ethyl acetate-pH 3·3 buffer partition system supported on Celite. Chromatographic separation is followed by measuring the absorbance of the eluate at 263 nm. The system enables the determination of oxytetracycline to be made in the presence of anhydro-oxytetracycline, chlortetracycline, α- and β-apo-oxytetracycline, and epi-oxytetracycline, the last three being the most likely contaminants of crude material.

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Key concepts: Oxytetracycline, Chromatography, Chemistry, Elution, Absorbance, Chlortetracycline, Hexane, Antibiotics