2008•Iranian journal of pharmacology & therapeuticsRequires access

Pathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned From Preconditioning and Postconditioning?

Pitchai Balakumar, Bharat Pateliya, Gurfateh Singh, Manjeet Singh

Abstract

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechanisms involved in the pathophysiology of ischemia/reperfusion injury. Moreover, the pharmacology of preconditioning and postconditioning is delineated.

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Key concepts: Ischemia, Pathophysiology, Reperfusion injury, Medicine, Pharmacology, Ischemic preconditioning, Myocardial ischemia, Cardiology