2010•Applied and Environmental MicrobiologyOpen access

Novel Structural Elements within the Nonproteolytic Clostridium botulinum Type F Toxin Gene Cluster

Nir Dover, Jason R. Barash, Kelly Kearfott Hill, John C. Detter, Stephen S. Arnon

Abstract

We sequenced for the first time the complete neurotoxin gene cluster of a nonproteolytic Clostridium botulinum type F. The neurotoxin gene cluster contained a novel gene arrangement that, compared to other C. botulinum neurotoxin gene clusters, lacked the regulatory botR gene and contained an intergenic is element between its orfX2 and orfX3 genes.

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Key concepts: Clostridium botulinum, Neurotoxin, Gene cluster, Gene, Clostridiaceae, Toxin, Biology, Genetics