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2008•Medical MycologyRequires access

In vitrointeraction of terbinafine with itraconazole and amphotericin B against fungi causing chromoblastomycosis in China

Jin Yu, Ruoyu Li, Min Zhang, Li Liu, Zhe Wan

Open publisher page 31 citations

Abstract

The combined effects of terbinafine with itraconazole and amphotericin B against Cladophialophora carrionii, Phialophora verrucosa and Fonsecaea pedrosoi were evaluated in vitro by the checker-board method and expressed as a fractional inhibitory concentration (FIC) index. Synergy was observed with the combination of terbinafine and itraconazole against one isolate of C. carrionii and no antagonism was observed. When amphotericin B was combined with terbinafine or itraconazole, no synergy or antagonism was noted with all isolates included in this investigation.

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What this paper is about

The combined effects of terbinafine with itraconazole and amphotericin B against Cladophialophora carrionii, Phialophora verrucosa and Fonsecaea pedrosoi were evaluated in vitro by the checker-board method and expressed as a fractional inhibitory concentration (FIC) index. Synergy was observed with the combination of terbinafine and itraconazole against one isolate of C. carrionii and no antagonism was observed. When amphotericin B was combined with terbinafine or itraconazole, no synergy or antagonism was noted with all isolates included in this investigation.

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OpenAlex reports 31 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The combined effects of terbinafine with itraconazole and amphotericin B against Cladophialophora carrionii, Phialophora verrucosa and Fonsecaea pedrosoi were evaluated in vitro by the checker-board method and expressed as a fractional inhibitory concentration (FIC) index. Synergy was observed with the combination of terbinafine and itraconazole against one isolate of C. carrionii and no antagonism was observed. When amphotericin B was combined with terbinafine or itraconazole, no synergy or antagonism was noted with all isolates included in this investigation.

Key concepts: Terbinafine, Itraconazole, Chromoblastomycosis, Antagonism, Amphotericin B, Microbiology, In vitro, Fluconazole

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In vitrointeraction of terbinafine with itraconazole and amphotericin B against fungi causing chromoblastomycosis in China — Research Paper | ScholarLens