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2009•Journal of Pharmacy ResearchRequires access

Hepatoprotective activity of the alcoholic extract of the dried leaves of Cassia alata, Linn.

Ramasamy Anandan, Balasundaram Jayakar, Rajappan Manavalan

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Abstract

Hepatoprotective activity of the Acoholic Extract(95%) of the dried leaves of Cassia alata (ECA) was studied against Paracetamol induced hepatic injury in albino rats. Pretreatment of the ECA reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Histopathological observations also revealed that pretreatment with ECA protected the animals from paracetamol induced liver damage. The results indicate that the leaves of C.alata possess the Hepatoprotective activity. This property may be attributed to the flavonoids present in the leaves of C.alata.

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What this paper is about

Hepatoprotective activity of the Acoholic Extract(95%) of the dried leaves of Cassia alata (ECA) was studied against Paracetamol induced hepatic injury in albino rats. Pretreatment of the ECA reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Histopathological observations also revealed that pretreatment with ECA protected the animals from paracetamol induced liver damage. The results indicate that the leaves of C.alata possess the Hepatoprotective activity. This property may be attributed to the flavonoids present in the leaves of C.alata.

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Available abstract

Hepatoprotective activity of the Acoholic Extract(95%) of the dried leaves of Cassia alata (ECA) was studied against Paracetamol induced hepatic injury in albino rats. Pretreatment of the ECA reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Histopathological observations also revealed that pretreatment with ECA protected the animals from paracetamol induced liver damage. The results indicate that the leaves of C.alata possess the Hepatoprotective activity. This property may be attributed to the flavonoids present in the leaves of C.alata.

Key concepts: Cassia, Alkaline phosphatase, Traditional medicine, Bilirubin, Liver injury, Chemistry, Hepatoprotection, Medicinal plants

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Hepatoprotective activity of the alcoholic extract of the dried leaves of Cassia alata, Linn. — Research Paper | ScholarLens