2010•ChemCatChemRequires access

Directed Evolution of Enantioconvergency: The Case of an Epoxide Hydrolase‐Catalyzed Reaction of a Racemic Epoxide

Huabao Zheng, Daniel Kahakeaw, Juan Pablo Acevedo, Manfred T. Reetz

Abstract

Highly evolved: The Aspergillus niger epoxide hydrolase (ANEH) has been subjected to laboratory evolution with the creation of mutants that transform the racemic epoxide to a single stereoisomer with greater than 90 % conversion and 99 % enantiomeric excess.

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Key concepts: Epoxide hydrolase, Epoxide, Enantiomer, Aspergillus niger, Enantiomeric excess, Chemistry, Kinetic resolution, Biocatalysis