1975•The Journal of Experimental MedicineOpen access

Autologous stimulation of human lymphocyte subpopulation.

Gerhard Opelz, Masahiro Kiuchi, Mitsuo Takasugi, P I Terasaki

Abstract

The background stimulation universally seen when lymphocytes are cultured in vitro has been shown to be markedly lowered by reducing the proportion of B lymphocytes. B-rich fractions of lymphocytes had extremely high background stimulation. It is concluded that stimulation of T cells, probably by autologous B cells, provides the most probable explanation for the findings described.

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Key concepts: Stimulation, In vitro, Lymphocyte, Immunology, Lymphocyte activation, Chemistry, Biology, Molecular biology