1975•Journal of NeurochemistryRequires access

INHIBITION OF 5′‐NUCLEOTIDASE IN RAT BRAIN BY METHYLXANTHINES

Junji Tsuzuki, R.W. Newburgh

Abstract

Abstract —Rat brain 5′‐nucleotidase (EC 3.1.3.5) is inhibited by methylxanthines such as theophylline. Inhibition of the 5′‐nucleotidase by theophylline appears more efficient than the inhibition of cAMP phosphodiesterase by this drug. A similar inhibition is observed with caffeine, theobromine, 7′‐methyl‐xanthine and 1‐methylxanthine.

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Key concepts: Theophylline, Theobromine, Caffeine, Xanthine, Aminophylline, Phosphodiesterase, 5'-nucleotidase, Chemistry