1970Archives of Disease in ChildhoodOpen access

Dystonic Reactions in Children Caused by Metoclopramide

Maria Casteels‐Van Daele, Jaak Jaeken, P. Van Der Schueren, A. Zimmerman, P. Van Den Bon

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Abstract

Five cases of alarming dystonic reactions are reported in children receiving a normal dosage of metoclopramide, a new anti-emetic drug. The symptomatology consisted mainly of neck pain, torticollis, retrocollis, oculogyric crisis, and trismus, and patients were admitted with presumed diagnoses of encephalitis, meningitis, and tetanus. After discontinuing the drug, all symptoms disappeared completely. We believe that metoclopramide should be used with caution in paediatrics and that all doctors should be familiar with its possible bizarre side-effects.

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Five cases of alarming dystonic reactions are reported in children receiving a normal dosage of metoclopramide, a new anti-emetic drug. The symptomatology consisted mainly of neck pain, torticollis, retrocollis, oculogyric crisis, and trismus, and patients were admitted with presumed diagnoses of encephalitis, meningitis, and tetanus. After discontinuing the drug, all symptoms disappeared completely. We believe that metoclopramide should be used with caution in paediatrics and that all doctors should be familiar with its possible bizarre side-effects.

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Available abstract

Five cases of alarming dystonic reactions are reported in children receiving a normal dosage of metoclopramide, a new anti-emetic drug. The symptomatology consisted mainly of neck pain, torticollis, retrocollis, oculogyric crisis, and trismus, and patients were admitted with presumed diagnoses of encephalitis, meningitis, and tetanus. After discontinuing the drug, all symptoms disappeared completely. We believe that metoclopramide should be used with caution in paediatrics and that all doctors should be familiar with its possible bizarre side-effects.

Key concepts: Medicine, Metoclopramide, Torticollis, Trismus, Pediatrics, Anesthesia, Surgery, Vomiting

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