2007•ChemBioChemRequires access

Development of an Activity‐Based Probe for Steroid Sulfatases

Chun‐Ping Lu, Chien‐Tai Ren, Shih‐Hsiung Wu, Chi‐Yuan Chu, Lee‐Chiang Lo

Abstract

Selecting sulfatase. By loading probe 1 onto beads, we have demonstrated a protocol that allows for the selective labeling of a human steroid sulfatase (STS) from crude overexpressed preparations. The development of probe 1 will offer great opportunities in sulfatase-related research, including rapid screening for this class of enzymes and for their inhibitors.

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Available abstract

Key concepts: Steroid sulfatase, Sulfatase, Steroid, Enzyme, Chemistry, Biochemistry, Computational biology, Biology