2009•Angewandte Chemie International EditionRequires access

Asymmetric Self‐ and Cross‐Aldol Reactions of Glycolaldehyde Catalyzed by D ‐Fructose‐6‐phosphate Aldolase

Xavier Garrabou, José Antonio Castillo, Christine Guérard‐Hélaine, Teodor Parella, Jesús Joglar, Marielle Lemaire, Pere Clapés

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Abstract

New facets of enzyme activity: D-Fructose-6-phosphate aldolase (FSA) catalyzes the self-aldol reaction of glycolaldehyde (GA) and its cross-aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross-aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low.

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Key concepts: Aldol reaction, Glycolaldehyde, Aldolase A, Chemistry, Glyceraldehyde, Aldehyde, Aldolase B, Fructose