ScholarLens Back to search
1996•Vox SanguinisRequires access

X‐Irradiation Does Not Affect the Levels of Complement Regulatory Proteins, CD35 (CR1), CD55 (DAF) and CD59 on Concentrated Red Cells

Yasuo Fukumori, Tsukasa Seya, Shiro Ohnoki, Hirotoshi Shibata, Hideo Yamaguchi

Open publisher page 0 citations

Abstract

Abstract Human erythrocytes express complement (C) regulatory proteins, C3b/C4b receptor (CR1, CD35), decay‐accelerating factor (DAF, CD55) and CD59, which protect cells from autologous C attack [ 1 ]. CR1 and DAF are C3‐step regulators which destabilize the classical and alternative C3 convertases [ 1 ]. In addition, CR1 can bind C4b and C3b in the immune complexes to clear them from the circulation, namely immune adherence [ 2 ]. CD59 inhibits the formation of membrane attack complexes [ 1 ].

About this research paper

What this paper is about

Abstract Human erythrocytes express complement (C) regulatory proteins, C3b/C4b receptor (CR1, CD35), decay‐accelerating factor (DAF, CD55) and CD59, which protect cells from autologous C attack [ 1 ]. CR1 and DAF are C3‐step regulators which destabilize the classical and alternative C3 convertases [ 1 ]. In addition, CR1 can bind C4b and C3b in the immune complexes to clear them from the circulation, namely immune adherence [ 2 ]. CD59 inhibits the formation of membrane attack complexes [ 1 ].

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Abstract Human erythrocytes express complement (C) regulatory proteins, C3b/C4b receptor (CR1, CD35), decay‐accelerating factor (DAF, CD55) and CD59, which protect cells from autologous C attack [ 1 ]. CR1 and DAF are C3‐step regulators which destabilize the classical and alternative C3 convertases [ 1 ]. In addition, CR1 can bind C4b and C3b in the immune complexes to clear them from the circulation, namely immune adherence [ 2 ]. CD59 inhibits the formation of membrane attack complexes [ 1 ].

Key concepts: CD59, Decay-accelerating factor, Complement receptor 1, Complement system, CD46, Cell biology, Receptor, Immune system

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
X‐Irradiation Does Not Affect the Levels of Complement Regulatory Proteins, CD35 (CR1), CD55 (DAF) and CD59 on Concentrated Red Cells — Research Paper | ScholarLens