Séamus O’Reilly
Abstract
Topotecan is a semisynthetic water soluble analogue of camptothecin, which exerts its cytotoxic effects through inhibition of the enzyme topoisomerase I. This enzyme relaxes supercoiled DNA by covalently binding to it, leading to transient single-strand breaks that are resealed by topoisomerase I
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Topotecan is a semisynthetic water soluble analogue of camptothecin, which exerts its cytotoxic effects through inhibition of the enzyme topoisomerase I. This enzyme relaxes supercoiled DNA by covalently binding to it, leading to transient single-strand breaks that are resealed by topoisomerase I
Key concepts: Topotecan, Topoisomerase, Camptothecin, Enzyme, Chemistry, Enzyme inhibitor, Pharmacology, DNA supercoil