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Sperm–Egg Interactions: Sperm–Egg Binding in Mammals

Janice P. Evans, Daniel M. Hardy, Bayard T. Storey

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Abstract

Abstract Fertilization of the mammalian egg occurs through an ordered sequence of reactions in which the sperm adheres to, then penetrates, the zona pellucida. It then binds to and then fuses with the egg's plasma membrane, so that the gametes fuse to form the zygote. The zona pellucida and egg plasma membrane are then modified after fertilization to block polyspermic fertilization. The interactions between the sperm and egg involve specific molecules on both gametes that mediate the interactions; malfunction may cause infertility.

About this research paper

What this paper is about

Abstract Fertilization of the mammalian egg occurs through an ordered sequence of reactions in which the sperm adheres to, then penetrates, the zona pellucida. It then binds to and then fuses with the egg's plasma membrane, so that the gametes fuse to form the zygote. The zona pellucida and egg plasma membrane are then modified after fertilization to block polyspermic fertilization. The interactions between the sperm and egg involve specific molecules on both gametes that mediate the interactions; malfunction may cause infertility.

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Available abstract

Abstract Fertilization of the mammalian egg occurs through an ordered sequence of reactions in which the sperm adheres to, then penetrates, the zona pellucida. It then binds to and then fuses with the egg's plasma membrane, so that the gametes fuse to form the zygote. The zona pellucida and egg plasma membrane are then modified after fertilization to block polyspermic fertilization. The interactions between the sperm and egg involve specific molecules on both gametes that mediate the interactions; malfunction may cause infertility.

Key concepts: Zona pellucida, Zygote, Human fertilization, Polyspermy, Sperm, Oocyte, Biology, Cell biology

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