1996•Antimicrobial Agents and ChemotherapyOpen access

In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species

A L Barry, Steven D. Brown

Abstract

A new triazole derivative (voriconazole or UK-109,496) and fluconazole were tested against 249 isolates of Candida spp. representing six species. Voriconazole was 10 to 100 times more potent than fluconazole. Strains with decreased susceptibility to fluconazole were inhibited by relatively low concentrations of voriconazole.

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Key concepts: Voriconazole, Fluconazole, Triazole, Antifungal, Microbiology, In vitro, Biology, Fungicide