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Intermediate Filaments in DMBA‐Induced Mammary Adenocarcinomas in Rats

L. Peña, Juana M. Flores, M. Castaño, Mónica González

Abstract

Experimental DMBA (7,12-dimethylbenzanthracene)-induced mammary tumours in rats were studied. Microscopic examination revealed a high rate of adenocarcinomas (95.3% in 148 mammary tumours studied). An immunohistochemical study of cytoskeleton intermediate filaments (I.F.) showed cytokeratins in neoplastic epithelial cells; myoepithelial cells expressed cytokeratins, vimentin and desmin. Finally we propose the immunocytochemical localization of desmin as a useful method to recognize myoepithelial proliferation areas in mammary tumours.

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Key concepts: Myoepithelial cell, Desmin, DMBA, Intermediate filament, Vimentin, Immunohistochemistry, Pathology, Mammary tumor