2006•Antimicrobial Agents and ChemotherapyOpen access

Rapid Emergence of Resistance to Linezolid during Linezolid Therapy of an Enterococcus faecium Infection

Jamela Seedat, Günther Zick, Ingo Klare, Carola Konstabel, Norbert Weiler, Hany Sahly

Abstract

We report the emergence of linezolid resistance (MICs of 16 to 32 mg/liter) in clonally related vancomycin-susceptible and -resistant Enterococcus faecium isolates from an intensive care unit patient after 12 days of linezolid therapy. Only linezolid-susceptible isolates of the same clone were detected at 28 days after termination of linezolid therapy.

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Available abstract

Key concepts: Linezolid, Enterococcus faecium, Enterococcus, Microbiology, Medicine, Vancomycin, clone (Java method), Vancomycin-resistant Enterococcus