1985•Antimicrobial Agents and ChemotherapyOpen access

In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae

W S Ng, P. Y. Chau, Y.K. Leung, P. C. Wong

Abstract

Ro 15-8074, a new cephalosporin the pivaloyloxymethylester of which (Ro 15-8075) is orally absorbable, showed greater in vitro activity than cefaclor against 48 Neisseria gonorrhoeae strains, including 25 penicillinase-producing strains. Unlike cefaclor, Ro 15-8074 was unaffected by increase in inoculum size, and it exhibited a remarkable stability against gonococcal beta-lactamase hydrolysis.

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Key concepts: Neisseria gonorrhoeae, Cefaclor, Cephalosporin, Microbiology, In vitro, Neisseriaceae, Chemistry, Antibacterial agent