2015•Science AdvancesOpen access
Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation
Jun Tang, Mark E. Lobatto, Laurien Hassing, Susanne E. M. van der Staay, Sarian M. van Rijs, Claudia Calcagno, Mounia Sabrina Braza, Samantha Baxter, François Fay, Brenda L. Sánchez-Gaytán, Raphaël Duivenvoorden, Hendrik B. Sager, Yaritzy M. Astudillo, Wei Leong, Sarayu Ramachandran, Gert Storm, Carlos Pérez‐Medina, Thomas Reiner, David P. Cormode, Gustav J. Strijkers, Erik S.G. Stroes, Filip K. Świrski, Matthias Nahrendorf, Edward A A Fisher, Zahi Adel Fayad, Willem J. M. Mulder
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Abstract
) with advanced atherosclerotic plaques. This resulted in rapid reduction of plaque inflammation and favorable phenotype remodeling. We then combined this short-term nanoparticle intervention with an eight-week oral statin treatment, and this regimen rapidly reduced and continuously suppressed plaque inflammation. Our results demonstrate that pharmacologically inhibiting local macrophage proliferation can effectively treat inflammation in atherosclerosis.
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