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1978•Journal of Antimicrobial ChemotherapyRequires access

A view of multiple drug resistance in Neisseria gonorrhoeae

M. Chan, M. Goldner

Open publisher page 7 citations

Abstract

Resistance to penicillin and tetracycline occurs in Neisseria gonorrhoeae yet the biochemical mechanism is unknown. Binding of [14C]-penicillin and absorption of [3H]-tetracycline were assayed in the range of minimum inhibitory concentration levels, to compare sensitive and multiple drug resistant strains of N. gonorrhoeae. Levels for both drugs were significantly higher in the sensitive strains. However, the effect of temperature differential on drug concentration pattern indicated that interference on the part of the resistant cell for penicillin related to passive diffusion and for tetracycline to facilitated diffusion. Thus, resistance in common to penicillin and tetracycline does not appear to rely on the outer membrane in N. gonorrhoeae.

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What this paper is about

Resistance to penicillin and tetracycline occurs in Neisseria gonorrhoeae yet the biochemical mechanism is unknown. Binding of [14C]-penicillin and absorption of [3H]-tetracycline were assayed in the range of minimum inhibitory concentration levels, to compare sensitive and multiple drug resistant strains of N. gonorrhoeae. Levels for both drugs were significantly higher in the sensitive strains. However, the effect of temperature differential on drug concentration pattern indicated that interference on the part of the resistant cell for penicillin related to passive diffusion and for tetracycline to facilitated diffusion. Thus, resistance in common to penicillin and tetracycline does not appear to rely on the outer membrane in N. gonorrhoeae.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Resistance to penicillin and tetracycline occurs in Neisseria gonorrhoeae yet the biochemical mechanism is unknown. Binding of [14C]-penicillin and absorption of [3H]-tetracycline were assayed in the range of minimum inhibitory concentration levels, to compare sensitive and multiple drug resistant strains of N. gonorrhoeae. Levels for both drugs were significantly higher in the sensitive strains. However, the effect of temperature differential on drug concentration pattern indicated that interference on the part of the resistant cell for penicillin related to passive diffusion and for tetracycline to facilitated diffusion. Thus, resistance in common to penicillin and tetracycline does not appear to rely on the outer membrane in N. gonorrhoeae.

Key concepts: Neisseria gonorrhoeae, Tetracycline, Penicillin, Microbiology, Minimum inhibitory concentration, Drug resistance, Neisseriaceae, Antibiotics

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