2006•Journal of BacteriologyOpen access

Derepression of Excision of Integrative and Potentially Conjugative Elements from Streptococcus thermophilus by DNA Damage Response: Implication of a cI-Related Repressor

Xavier Bellanger, Catherine Morel, Bernard Decaris, Gérard Guédon

Abstract

A DNA-damaging agent, mitomycin C, derepresses the site-specific excision of two integrative and potentially conjugative elements from Streptococcus thermophilus, ICESt1 and ICESt3. The regulation pathway involves a repressor related to phage lambda cI repressor. It could also involve a putative regulator related to another type of phage repressors, the "cI-like" repressors.

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Key concepts: Derepression, Repressor, Biology, Streptococcus thermophilus, Genetics, DNA, Regulator, DNA damage