2004•PubMedOpen access

Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats.

Yoshihisa Kitamura, Hiroaki Araki, Tadashi Nagatani, Katsuyuki Takao, Kazuhiko Shibata, Yutaka Gomita

Abstract

We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.

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Key concepts: Imipramine, Behavioural despair test, Depression (economics), Medicine, Animal model, Chronic stress, Internal medicine, Endocrinology