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1978•Angewandte Chemie International Edition in EnglishRequires access

Correlation of the Absolute Configuration of Chiral Epoxides by Complexation Chromatography; Synthesis and Enantiomeric Purity of (+)‐ and (−)‐1,2‐Epoxypropane

Volker Schurig, Bernhard Koppenhöfer, Waldemar Bürkle

Open publisher page 44 citations

Abstract

Chiroptical properties of chiral substrates can be determined by complexation chromatography. 10-9 g of crude, non-derivatized substance suffice for determination of optical purity; the rotation of the pure enantiomer need not be known. Moreover, the absolute configuration of three-membered ring heterocycles can be deduced from their retention behavior on a special nickel complex with the aid of a quadrant rule for (1), XNH, O, S.

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Chiroptical properties of chiral substrates can be determined by complexation chromatography. 10-9 g of crude, non-derivatized substance suffice for determination of optical purity; the rotation of the pure enantiomer need not be known. Moreover, the absolute configuration of three-membered ring heterocycles can be deduced from their retention behavior on a special nickel complex with the aid of a quadrant rule for (1), XNH, O, S.

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Available abstract

Chiroptical properties of chiral substrates can be determined by complexation chromatography. 10-9 g of crude, non-derivatized substance suffice for determination of optical purity; the rotation of the pure enantiomer need not be known. Moreover, the absolute configuration of three-membered ring heterocycles can be deduced from their retention behavior on a special nickel complex with the aid of a quadrant rule for (1), XNH, O, S.

Key concepts: Absolute configuration, Optical rotation, Enantiomer, Chemistry, Enantiomeric excess, Specific rotation, Ring (chemistry), Nickel

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Correlation of the Absolute Configuration of Chiral Epoxides by Complexation Chromatography; Synthesis and Enantiomeric Purity of (+)‐ and (−)‐1,2‐Epoxypropane — Research Paper | ScholarLens