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2004•Journal of Korean Medical ScienceOpen access

A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication

Soo‐Youn Lee, Chang‐Seok Ki, Kyung Sue Hong, Jong‐Won Kim

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Abstract

A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline MedicationWe present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT).Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B.This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.

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A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline MedicationWe present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT).Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B.This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.

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Available abstract

A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline MedicationWe present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT).Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B.This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.

Key concepts: Nortriptyline, CYP2D6, Pharmacogenetics, Pharmacology, Adverse effect, Constipation, Medicine, Debrisoquine

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