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2003•Unpublished venueRequires access

Mechanisms of elastin calcification and its prevention with aluminum chloride pretreatment

Narendra Vyavahare, Matthew Ogle, F J Schoen, Robert J. Levy

Open publisher page 1 citations

Abstract

Elastin calcification occurs in bioprosthetic heart valve implants. The authors have developed a rat subdermal model to study purified elastin calcification. Purified elastin implants undergo severe calcification within 21 day period and it is found to be poorly crystallin hydroxyapatite by X-ray analysis. Aluminum chloride pretreatment of elastin inhibits its calcification due to the strong binding of aluminum ions to elastin leading to the alteration in elastin structures.

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What this paper is about

Elastin calcification occurs in bioprosthetic heart valve implants. The authors have developed a rat subdermal model to study purified elastin calcification. Purified elastin implants undergo severe calcification within 21 day period and it is found to be poorly crystallin hydroxyapatite by X-ray analysis. Aluminum chloride pretreatment of elastin inhibits its calcification due to the strong binding of aluminum ions to elastin leading to the alteration in elastin structures.

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Available abstract

Elastin calcification occurs in bioprosthetic heart valve implants. The authors have developed a rat subdermal model to study purified elastin calcification. Purified elastin implants undergo severe calcification within 21 day period and it is found to be poorly crystallin hydroxyapatite by X-ray analysis. Aluminum chloride pretreatment of elastin inhibits its calcification due to the strong binding of aluminum ions to elastin leading to the alteration in elastin structures.

Key concepts: Elastin, Calcification, Chemistry, Aluminium, Chloride, Biochemistry, Internal medicine, Pathology

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