2005•Antimicrobial Agents and ChemotherapyOpen access

Activities of Flucytosine, Fluconazole, Amphotericin B, and Micafungin in a Murine Model of Disseminated Infection by Candida glabrata

Marçal Mariné, Carolina Serena, Belkys Fernández-Torres, F. Javier Pastor, Josep Guarro

Abstract

We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.

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Key concepts: Flucytosine, Micafungin, Amphotericin B, Candida glabrata, Fluconazole, Microbiology, Spleen, Mycosis