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1986•Journal of HygieneOpen access

The antigenic analysis of haemorrhagic fever with renal syndrome viruses in China by monoclonal antibodies

Xu Zhang, Xinyue An, M. X. Wang

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Abstract

Thirty-six strains of haemorrhagic fever with renal syndrome (HFRS) virus were isolated from patients and a number of host animals in various areas in China. They were analysed by an immunofluorescence test (IFAT) using 10 monoclonal antibodies (McAbs) specific for the HFRS virus; antigenic differences among the strains have been demonstrated. The HFRS virus strains revealed nine different reactions with the McAbs, showing that there are at least nine different antigenic determinants including group-, type- and strain-specific. Analysis of the results shows that antigenic differences among the HFRS virus strains are mainly related to differences in the host animals.

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Thirty-six strains of haemorrhagic fever with renal syndrome (HFRS) virus were isolated from patients and a number of host animals in various areas in China. They were analysed by an immunofluorescence test (IFAT) using 10 monoclonal antibodies (McAbs) specific for the HFRS virus; antigenic differences among the strains have been demonstrated. The HFRS virus strains revealed nine different reactions with the McAbs, showing that there are at least nine different antigenic determinants including group-, type- and strain-specific. Analysis of the results shows that antigenic differences among the HFRS virus strains are mainly related to differences in the host animals.

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Available abstract

Thirty-six strains of haemorrhagic fever with renal syndrome (HFRS) virus were isolated from patients and a number of host animals in various areas in China. They were analysed by an immunofluorescence test (IFAT) using 10 monoclonal antibodies (McAbs) specific for the HFRS virus; antigenic differences among the strains have been demonstrated. The HFRS virus strains revealed nine different reactions with the McAbs, showing that there are at least nine different antigenic determinants including group-, type- and strain-specific. Analysis of the results shows that antigenic differences among the HFRS virus strains are mainly related to differences in the host animals.

Key concepts: Virology, Monoclonal antibody, Virus, Antigen, Biology, Immunofluorescence, Antibody, Antigenic variation

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