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2012•Angewandte Chemie International EditionOpen access

Intramolecular Alkoxycyanation and Alkoxyacylation Reactions: New Types of Alkene Difunctionalizations for the Construction of Oxygen Heterocycles

John P. Wolfe

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Abstract

Functionalized dihydrobenzofuran derivatives can be obtained by intramolecular alkoxycyanation and alkoxyacylation of alkenes (see scheme). In both transformations, selective activation of an OFG bond is accomplished by using a transition-metal catalyst. These transformations represent a conceptually new approach to metal-catalyzed alkene difunctionalization.

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Functionalized dihydrobenzofuran derivatives can be obtained by intramolecular alkoxycyanation and alkoxyacylation of alkenes (see scheme). In both transformations, selective activation of an OFG bond is accomplished by using a transition-metal catalyst. These transformations represent a conceptually new approach to metal-catalyzed alkene difunctionalization.

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Available abstract

Functionalized dihydrobenzofuran derivatives can be obtained by intramolecular alkoxycyanation and alkoxyacylation of alkenes (see scheme). In both transformations, selective activation of an OFG bond is accomplished by using a transition-metal catalyst. These transformations represent a conceptually new approach to metal-catalyzed alkene difunctionalization.

Key concepts: Intramolecular force, Alkene, Catalysis, Chemistry, Transition metal, Combinatorial chemistry, Metal, Organic chemistry

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