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1976•Biology of ReproductionOpen access

Induction of Ovulation in Premenarchial Rhesus Monkeys with Human Gonadotropins1

Gerson Weiss, Ira Rifkin, Linda E. Atkinson

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Abstract

Five premenarchial rhesus monkeys were treated with human menopausal gonadotropin (HMG) and chorionic gonadotropin (HCG) to induce ovulation. All animals had large elevations in serum estradiol concentrations and perineal sex skin development in response to HMG injections. Four of five monkeys had peripheral progesterone concentrations suggestive of ovulation after HCG administration and corpora lutea were confirmed histologically in two animals. Thus, ovaries of reproductively immature monkeys are capable of steroid secretion and ovulation when provided with sufficient gonadotropin stimulation.

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Five premenarchial rhesus monkeys were treated with human menopausal gonadotropin (HMG) and chorionic gonadotropin (HCG) to induce ovulation. All animals had large elevations in serum estradiol concentrations and perineal sex skin development in response to HMG injections. Four of five monkeys had peripheral progesterone concentrations suggestive of ovulation after HCG administration and corpora lutea were confirmed histologically in two animals. Thus, ovaries of reproductively immature monkeys are capable of steroid secretion and ovulation when provided with sufficient gonadotropin stimulation.

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Available abstract

Five premenarchial rhesus monkeys were treated with human menopausal gonadotropin (HMG) and chorionic gonadotropin (HCG) to induce ovulation. All animals had large elevations in serum estradiol concentrations and perineal sex skin development in response to HMG injections. Four of five monkeys had peripheral progesterone concentrations suggestive of ovulation after HCG administration and corpora lutea were confirmed histologically in two animals. Thus, ovaries of reproductively immature monkeys are capable of steroid secretion and ovulation when provided with sufficient gonadotropin stimulation.

Key concepts: Ovulation, Human chorionic gonadotropin, Biology, Gonadotropin, Internal medicine, Endocrinology, Induced ovulation, Stimulation

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Induction of Ovulation in Premenarchial Rhesus Monkeys with Human Gonadotropins1 — Research Paper | ScholarLens