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1995•Australian and New Zealand Journal of SurgeryRequires access

HEPARIN‐REBOUND IN THE EARLY POSTOPERATIVE PHASE FOLLOWING CARDIOPULMONARY BYPASS

P. Subramaniam, Peter Skillington, James Tatoulis

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Abstract

The incidence of the 'heparin-rebound' phenomenon after protamine neutralization of systemic heparinization required for cardiopulmonary bypass (CPB) was investigated. Heparin-effect was detected in 43% of patients studied at 2 h, 31% at 4 h, and 37% at 8 h after reversal of circuit heparin on CPB. Heparin-rebound was shown to be associated with a small but significant increase in postoperative bleeding which was not of clinical importance.

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What this paper is about

The incidence of the 'heparin-rebound' phenomenon after protamine neutralization of systemic heparinization required for cardiopulmonary bypass (CPB) was investigated. Heparin-effect was detected in 43% of patients studied at 2 h, 31% at 4 h, and 37% at 8 h after reversal of circuit heparin on CPB. Heparin-rebound was shown to be associated with a small but significant increase in postoperative bleeding which was not of clinical importance.

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OpenAlex reports 22 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The incidence of the 'heparin-rebound' phenomenon after protamine neutralization of systemic heparinization required for cardiopulmonary bypass (CPB) was investigated. Heparin-effect was detected in 43% of patients studied at 2 h, 31% at 4 h, and 37% at 8 h after reversal of circuit heparin on CPB. Heparin-rebound was shown to be associated with a small but significant increase in postoperative bleeding which was not of clinical importance.

Key concepts: Medicine, Cardiopulmonary bypass, Heparin, Anesthesia, Cardiology, Surgery

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HEPARIN‐REBOUND IN THE EARLY POSTOPERATIVE PHASE FOLLOWING CARDIOPULMONARY BYPASS — Research Paper | ScholarLens