2013•MoleculesOpen access

Oligonucleotide Labelling Using a Fluorogenic “Click” Reaction with a Hemicarboxonium Salt

Marie‐Pierre Maether, K. K. Lapin, Andreea Muntean, Corinne Payrastre, Jean‐Marc Escudier

Abstract

Two fluorescent streptocyanine labelled oligonucleotides have been synthesized by a simple "click" reaction between a non-fluorescent hemicarboxonium salt and aminoalkyl functionalized thymidines within the oligonucleotide and their spectrophotometric properties have been studied.

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Key concepts: Oligonucleotide, Labelling, Click chemistry, Salt (chemistry), Fluorescence, Combinatorial chemistry, Chemistry, Fluorescent labelling