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2015•Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)Open access

CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145

Fatma Sri Wahyuni, Johnson Stanslas, Nordin H. Lajis, Dachriyanus Dachriyanus

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Abstract

Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines.

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Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines.

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Available abstract

Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines.

Key concepts: Cytotoxicity, MCF-7, Hydroquinone, MTT assay, Chemistry, Stereochemistry, Cell culture, Molecular biology

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CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145 — Research Paper | ScholarLens